If you are experiencing symptoms of bipolar-related depression…
You may qualify for if you:
Are 18-65 years old
Have been diagnosed with bipolar I disorder
Have been depressed for 1-18 months
Are currently experiencing a major depressive episode (symptoms of depression) 
Other study eligibility requirements may apply
Sign Up
What happens if I sign up?
If you think you might like to participate in the Illuminate1 Study, or would like more information, please fill out the questionnaire below so we can see if you qualify and can contact you about the study. Keep in mind that participation is entirely voluntary.
If you pass the initial screener, we will match you to an Illuminate1 Study location in your area or notify you when one becomes available. If there is not a current study for bipolar I depression in your area, we may reach out to you in the future via email, phone, or text to share information about new study opportunities that may be a good fit.
About Bipolar I Depression
People diagnosed with bipolar I disorder experience extreme mood swings, including intense periods of depression. Bipolar I depression often involves deep sadness, low or no energy, and suicidal thoughts.1
Bipolar I depressive episodes are typically longer than mixed or manic phases (periods of extreme energy and activity). One study found that patients with bipolar I disorder spent almost three times as many days in a depressed state than any other emotional state.3
Bipolar I depression can be severe and disrupt daily life and activities, with symptoms being the same as major depressive disorder:
- Persistent feelings of sadness or hopelessness
- Disinterest in regular activities and hobbies
- Difficulties sleeping at night/sleeping too much during the day
- Changes in appetite, weight gain or loss
- Feeling worthless, guilty, or “heavy”
- Issues with concentration/making decisions
- Thoughts about suicide or death2
Current treatments for bipolar I disorder and bipolar I depression include psychotherapy, mood stabilizers (e.g., lithium), antipsychotics, antidepressants, and combinations of antidepressants and antipsychotics.
Frequently Asked Questions
Consider joining a research study
We’re currently enrolling participants for the Illuminate1 Study.
What is a clinical research study?
A clinical research study (also called a clinical trial) is a medical study that helps to answer important questions about investigational medications, treatments, or devices—these may include how well study medications, treatments, or devices work for a certain condition. All medications must be tested in clinical trial before they can be submitted for approval and prescribed to patients.
Why are clinical trials important?
A clinical trial is the process by which new and innovative medications, interventions, and treatments are reviewed and analyzed before being potentially approved and brought to market.
Investigational medications have not been approved by regulatory authorities such as the Food and Drug Adminstration (FDA) and are not yet available to the public outside of a clinical trial setting. Even over-the-counter medications, such as NSAIDs you may have used to counteract a headache, have gone through the clinical trial process before they were available at your local pharmacy.
This clinical trial aims to determine whether the treatments may help reduce your bipolar I disorder-related depression. If the investigational medicine is effective, it may also support other patients with depressive episodes associated with bipolar I disorder.
What is the purpose of the Illuminate1 Study?
The purpose of the study is to test an oral, once-daily investigational medication to see whether it may reduce negative symptoms of bipolar I depression.
Will I be reimbursed/compensated?
Compensation may be available for those who qualify to take part in the study. You can discuss this further with the study team. There is no cost to participate in the study. Study-related care and treatments will be provided to you at no cost by a specialized medical team. Insurance is not required to participate.
What else do I need to consider?
The research team will be able to explain more about what the Illuminate1 Study involve, and it is up to you to decide if you want to take part. Participation in the study is voluntary. Whether or not you decide to participate in the study will not affect your current or future relationships with your doctors.
How far is the research study site?
If you qualify, we will match you to a study site closest to your home. If we are not currently running the study in your area, with your permission, we will keep you in our database and reach out once a study in your area becomes available. If, at any time, you decide you no longer want your information stored, you can opt out, and we will delete your details.
The Illuminate1 Study is looking to enroll approximately 320 participants experiencing bipolar I depression at 30 study sites located in the United States. The study will last up to 13 weeks, including a 6-week treatment phase and a 2-week follow-up period.
During this time, a dedicated medical team will provide participants with study-related care at no cost. Volunteers who qualify to take part in the study may be compensated or for their participation time and travel.
About the Illuminate1 Study
Who can participate?
You may be able to take part in the Illuminate1 Study if you:
- Are 18-65 years old
- Have been diagnosed with bipolar I disorder
- Have been depressed for 1-18 months
- Are currently experiencing a major depressive episode (symptoms of depression)
- Other study eligibility requirements may apply